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When Stephanie Bryant and Karin Payne submitted a $125,000 collaborative proposal for seed funding from the new AB Nexus initiative in 2020, they couldn鈥檛 imagine that only a few years later the project鈥攄eveloping new therapies to regenerate cartilage鈥攚ould be the catalyst for receiving n a $1.5 million grant from the National Science Foundation (NSF).听

The four-year NSF grant, awarded in 2021, is another reason for sufferers of chronic joint pain to be hopeful about the future, and today Bryant and Payne are applying for even larger federal grants to further advance their work. While their research is still in its early phases, the process that cultivated their collaboration is an achievement in its own right.

The 2020 seed grant proposal鈥攁 collaboration between Bryant (CU Boulder; Chemical and Biological Engineering) and Payne (CU Anschutz; School of Medicine, Orthopedics)鈥攔epresents more than the work of two of CU鈥檚 top researchers; it was an early sign that the AB Nexus initiative could help realize the vast potential of cultivating multidisciplinary collaborations across CU鈥檚 largest campuses.

鈥淚 think without AB Nexus, we probably would have never developed this new project,鈥� said Payne, who is currently working with Bryant to grow cartilage tissue organoids in the lab using stem cells.

Origins and early wins

In July 2020, the University of Colorado launched the initiative to expand research collaborations between the CU Anschutz and CU Boulder campuses. was to combine expertise in biosciences, engineering, biotechnology, space, pharmacology, public health, mental health and other areas of strength to drive innovation, earn competitive research awards from external sponsors, and amplify the impact of both campuses to improve lives.

The initiative has been steadfastly championed by the CU president鈥檚 office and leadership at both campuses, with a combined $3 million dedicated to the program through 2023.

In its first year, AB Nexus focused on paving the way for more productive collaborations by strengthening existing areas of connectivity and supporting joint proposals like the Bryant/Payne project. Additionally, the program invested in dedicated research partnership specialists on both campuses, enhanced proposal development support, and tackled some of the operational hurdles that could hinder effective cross-campus research partnerships.

By July 2021, AB Nexus had already provided $1.2 million in seed funding to 16 project teams, including the Bryant/Payne team. With a solid foundation of support services and funding in place, the program was now poised to accelerate collaborative, multidisciplinary research projects on an unprecedented scale for the听campuses.听听

Building momentum in year two

By the spring 2022 grant competition, Dan LaBarbera (CU Anschutz; Pharmaceutical Sciences) and Karolin Luger听(CU Boulder; Biochemistry) had become aware of the opportunity offered by AB Nexus. The University of Colorado Cancer Center was enthusiastic too, joining the effort as one of the first organizations to co-sponsor a seed grant.

The LaBarbera/Luger project was designed to explore a promising new compound for treating cancer. AB Nexus seed funding enabled the team to take important early steps toward identification and production of novel small molecule probes and lead drugs that target DNA damage repair and multi-drug resistance in cancer. This unique therapeutic strategy has the potential to improve treatments for many types of cancer鈥攊n particular breast, ovarian and pancreatic cancers.

LaBarbera sought out Luger鈥檚 expertise in structural biology for help identifying an efficient way to analyze a host of compounds to target cancer鈥攐ne of many AB Nexus examples of complementary disciplines combining seamlessly to tackle a vexing health problem.听听

The team, which described AB Nexus as 鈥渁n incredible opportunity and experience,鈥� also noted working with the campus commercialization arms鈥� at Anschutz and Venture Partners at CU Boulder鈥攁s a highlight of the experience. After all, discoveries in the lab are ultimately aimed at helping real-world patients.

Bridging gaps in year three

In the latest round of seed grant opportunities in spring 2023, a project led by Sidney D鈥橫ello (CU Boulder; Computer Science, Psychology and Neuroscience, Institute of Cognitive Science) and Patrick Romani (CU Anschutz; Psychiatry) was funded to study the occurrence of severe problem behaviors in youth who are prone to harmful鈥攁nd sometimes violent鈥攐utbursts.

Approaches for developmentally disabled youth with severe behavior problems currently fall short, often resulting in injury to family members and caregivers and property damage. Combining expertise in artificial intelligence (AI) with psychiatry, psychology, mathematics and neuroscience, the D鈥橫ello/Romani team aims to identify physiologic signals that predict the occurrence of severe problem behavior. Their research could lead to an early warning system for caregivers so they can help to reduce the frequency and severity of adverse outcomes鈥攁 true game-changer for families struggling with this challenge.

In this project, AB Nexus helped bridge a gap in each Principal Investigator鈥檚 research agenda: integrating behavioral science with innovative computational modeling.听

鈥淚 was really interested in this general line of research but knew that, with my clinical expertise, I was missing expertise in terms of being able to use complex methodologies to predict and to study these behaviors,鈥� said Romani, who works as a clinical psychologist at Children鈥檚 Hospital Colorado. 鈥淏eing able to collaborate and see things from a different perspective really helps break that ceiling so you can have a broader impact on the people you鈥檙e ultimately working for.鈥澨�

This team also depends on significant contributions from Research Scientist听Robert Moulder, who provides vital expertise in nonlinear modeling to illuminate how internal states affect observable behavior.听听

Because this area is a priority for the National Institute of Child Health and Development (NICHD), this team is well-positioned to unlock additional external federal funding to advance continued exploration into this promising area of research.听听

Three years of progress, a world of difference

Fast forward to fall 2023. The over six grant cycles embody the AB Nexus spirit, bringing together investigative teams from non-traditional collaborators to study important issues that require interdisciplinary expertise. Administrative obstacles have been removed, while collaborative support offices鈥攊ncluding regulatory units such as IRB and core facilities directors鈥攈ave also joined in the new, streamlined way of supporting intracampus research projects.

With three years of investment, progress and outcomes, program metrics bear out what the individual successes already suggest: AB Nexus is spurring more collaborations and the outcomes of those projects will eventually translate into life-changing solutions to improve human health and well-being.

Just as impactful as the number of new collaborations, proposals submitted and grants awarded, the research conducted is already informing clinical trials, aiding clinicians and shaping policy. Most important of all, AB Nexus projects are addressing some of the most challenging health problems facing our nation and the world鈥攁nd driving us ever closer to solutions.

鈥淭his program has really paid off,鈥� said Massimo Ruzzene, CU Boulder vice chancellor for research and innovation and dean of the institutes. 鈥淵ou can quantify the success of the program directly in the amount of research funding that it鈥檚 generated from outside sources.鈥�

What鈥檚 next for AB Nexus?

The collaborative seed grant program will continue full steam ahead in Spring 2024, including the introduction of award tracks to seed research in two new, key areas of opportunity: Climate Change and Health; and Artificial Intelligence/Advanced Computing and Health.听

The program structure will also evolve based on learning from the first three years: there will be one round of collaborative seed grants held annually in spring; the project period will be extended from 12 months to 18 months; and award amounts for new collaborations will increase from $50,000 to $75,000.

鈥淕reat things can happen, and unexpected sorts of questions can be asked, when we work together,鈥� said Flaig, 鈥渁nd I think that culture that鈥檚 being developed is really going to be one of those lasting things that AB Nexus can give us."

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