Publications

  1. Sekaran S and Park S. The Penultimate Step of Proteasomal ATPase Assembly is Mediated by a Switch Dependant on the Chaperone Nas2.Ìý
    Journal of Biological ChemistryÌý Jan 5;102870. doi:10.1016/j.jbc.2023.102870 (2023).
  2. Nahar A*, Sokolova V*, SekaranÌýS, Orth, JD, Park S. Assembly Checkpoint of the Proteasome Regulatory Particle is Activated by Coordinated Actions of Proteasomal ATPase Chaperones.
    Cell ReportsÌýJun 7;39(10):110918 (2022).Ìý*Equal contributions.
  3. Nahar A, Fu X, Polovin G, and Park S. Two Alternative Mechanisms Regulate the Onset of Chaperone-mediated Assembly of the Proteasomal ATPases.
    Journal of Biological ChemistryApr 19;294(16):6562-6577 (2019).
  4. Fu X†, Sokolova V†, Webb J, Old W, and Park S. Ubiquitin-mediated switch during assembly of the proteasomal ATPases mediated by Not4 ubiquitin ligase.
    PNAS, 115 (52):13246-13251 (2018). †Equal contributions.
  5. Zukowski A, Phillips J, Park S, Wu R, Gygi SP, and Johnson AM*. Proteomic Profiling of Yeast Heterochromatin Connects Direct Physical and Genetic Interactions.
    Current Genetics, Oct 12. doi: 10.1007/s00294-018-0889-6 (2018).
  6. Roelofs J, Suppahia A, Waite, K, and Park S. Native gel approaches in studying Proteasome Assembly and Chaperones.
    Methods in Molecular Biology, 1844:237-260 (2018).
  7. Marcus JM, Burke RT, Doak AE, Park S, and Orth JD*. Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death.
    Cell Cycle, Jul 23:1-16 (2018).
  8. Li F, Tian G, Langager D, Sokolova V, Finley D, and Park S. A nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone.
    PNAS, 114 (7): 1548–53 (2017).
  9. Sokolova V†, Li F†, Polovin G, and Park S. Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.
    Scientific Reports [Nature Press] 5:14909 (2015). †Equal contributions
  10. Park S†, Li X†, Kim HM†, Singh RC, Tian G, Hoyt MA, Lovell S, Battaile KP, Zolkiewski M, Coffino P, Roelofs P*, Cheng Y*, and Finley D*. Reconfiguration of the proteasome during chaperone-mediated assembly.
    Nature7450, 512-6 (2013). †Equal contributions
  11. Ehlinger A, Park S, Fahmy A, Lary J, Cole J, Finley D and Walters KJ*. Conformational Dynamics of the Proteasome ATPase Rpt6 and its Interaction with Rpn14.
    Structure5, 753-65 (2013).
  12. Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D*. An asymmetric interface between the regulatory particle and core particle of the proteasome.
    Nature Structural & Molecular Biology 18, 1259-67 (2011).
  13. Park S, Kim W, Tian G, Gygi SP, Finley D*. Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.
    Journal of Biological Chemistry 286, 36652-66 (2011).
  14. Lee BH†, Lee MJ†, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D*. Enhancement of proteasome activity by a small molecule inhibitor of USP14.
    Nature 467, 179-184 (2010). †Equal contributions,Ìý **Research Highlights. Protein degradation: Time for trimming.**Nature Reviews Molecular Cell Biology11, 754-5 (2010).
  15. Park S, Tian G, Roelofs J, Finley D*. Assembly manual for the proteasome regulatory particle: the first draft.
    Biochemical Society Transactions 38, 6-13 (2010).
  16. Park S, Roelofs J, Kim W, Robert J, Schmidt M, Gygi SP, Finley D*. Hexameric assembly of the proteasomal ATPases is templated through their C termini.
    Nature 459, 866-870 (2009).
  17. News and Views. The proteasome assembly line.
    Nature459, 787-788 (2009).
  18. Research Highlights. Protein degradation: Assembly from the base.
    Nature Reviews Molecular Cell Biology 10, 442-443 (2009).
    These two commentaries feature both #14Ìýpaper (Park et al., 2009) and #17Ìýpaper (Roelofs et al., 2009).
  19. Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley, D*. Chaperone-mediated pathway of proteasome regulatory particle assembly.
    Nature 459, 861-865 (2009).
  20. Kleijnen MF†, Roelofs J†, Park S, Hathaway NA, Glickman M, King RW, Finley D*. Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.
    Nature Structural & Molecular Biology 14, 1180-1188 (2007). †Equal contributions, **Research Roundup. A chewing proteasome is stabilized. Journal of Cell Biology179, 1086 (2007).
  21. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL*. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.
    Molecular Cell 27, 731-744 (2007). **Preview. Unlocking the proteasome door. Molecular Cell 27, 865-867 (2007).
  22. Park S, James CD*. ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner.
    Oncogene 24, 2495-2502 (2005).
  23. Park S, James CD*. Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism.
    Cancer Research 63, 723-727 (2003).
  24. Eley GD, Reiter JL, Pandita A, Park S, Jenkins RB, Maihle NJ, James CD*. A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma.
    Neuro-Oncology 4, 86-94 (2002).