Â鶹ÒùÔº

June 2024

ESC and iPSC

1. Capturing Totipotency in Human Cells through Spliceosomal Repression,Ìý, (Cell)
2. Applications, Challenges, and Prospects of Induced Pluripotent Stem Cells for Vascular Disease,Ìý, (Molecules and Cells)
3. X-chromosome Inactivation in Human iPSCs Provides Insight into X-Regulated Gene Expression in Autosomes,Ìý, (Genome Biology)
4. Advances and Challenges in Modeling Inherited Peripheral Neuropathies Using iPSCs,Ìý, (Experimental & Molecular Medicine)
5. The Relationship between Nanoscale Genome Organization and Gene Expression in Mouse Embryonic Stem Cells during Pluripotency Transition,Ìý, (Nucleic Acids Research)
6. Molecular Mechanism of BMP Signal Control by Twisted Gastrulation,Ìý, (Nature Communications)

Ìý

Neural

1. Developmental Origin of Oligodendrocytes Determines Their Function in the Adult Brain,Ìý, (Nature Neuroscience)
2. Protein Translation Rate Determines Neocortical Neuron Fate,Ìý, (Nature Communications)
3. The Necroptosis Cell Death Pathway Drives Neurodegeneration in Alzheimer’s Disease,Ìý, (Acta Neuropathologica)
4. Spinal Inhibitory Neurons Degenerate before Motor Neurons and Excitatory Neurons in a Mouse Model of ALS,Ìý, (Science Advances)
5. Multiscale Engineering of Brain Organoids for Disease Modeling,Ìý, (Advanced Drug Delivery Reviews)
6. Myelin Plasticity in the Ventral Tegmental Area Is Required for Opioid Reward,Ìý, (Nature)
7. Neuronal Activity-Driven O-GlcNAcylation Promotes Mitochondrial Plasticity,Ìý, (Developmental Cell)

Ìý

Cell Therapy

1. Transient Growth Factor Expression via mRNA in Lipid Nanoparticles Promotes Hepatocyte Cell Therapy in Mice,Ìý, (Nature Communications)
2. Heterologous Survey of 130 DNA Transposons in Human Cells Highlights Their Functional Divergence and Expands the Genome Engineering Toolbox,Ìý, (Cell)
3. Engineering Viral Vectors for Acoustically Targeted Gene Delivery,Ìý, (Nature Communications)
4. Bioactive-Material-Programmed CAR-T Cell Living Drug for Augmented Immunotherapy against Tumors,Ìý, (Cell Reports Physical Science)
5. Regenerative Medicine Act Passes Final Reading at Legislature,Ìý, (Focus Taiwan)

Ìý

Ìý

Organoid

1. Next-Generation Modeling of Cancer Using Organoids,Ìý, (Cold Spring Harbor Perspectives In Medicine)
2. A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development,Ìý, (Advanced Healthcare Materials)
3. Mice Hepatic Organoids for Modeling Nonalcoholic Fatty Liver Disease and Drug Response,, (Stem Cells and Development)
4. A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids,Ìý, (Analytical Chemistry)
5. A Novel Thin Plate Spline Methodology to Model Tissue Surfaces and Quantify Tumor Cell Invasion in Organ-on-Chip Models,Ìý, (Slas Discovery)
6. First-in-Kind Protocol for Creating Miniature Artificial Brains,Ìý, (TECH Explorist)
7. iPSC-Derived Hindbrain Organoids to Evaluate Escitalopram Oxalate Treatment Responses Targeting Neuropsychiatric Symptoms in Alzheimer’s Disease,Ìý, (Molecular Psychiatry)
8. Human Amniotic Mesenchymal Stem Cell-Islet Organoids Enhance the Efficiency of Islet Engraftment in a Mouse Diabetes Model,Ìý, (Life Sciences)

May 2024

ESC and IPSCÌý

• Single-Cell 3D Genome Structure Reveals Distinct Human Pluripotent StatesÌýÌý(Genome Biology)
• The First Two Blastomeres Contribute Unequally to the Human EmbryoÌýÌý(Cell)
• Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair PathwaysÌýÌý(Nature Communications)
• Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic TransitionÌýÌý(iScience)
• Scientists Are Trying to Get Cows Pregnant with Synthetic EmbryosÌýÌý(MIT Technology Review)
• Forward Programming Human Pluripotent Stem Cells into MicrogliaÌýÌý(Trends in Cell Biology)
• Cabinet Approves Two Draft Bills on Regenerative MedicineÌýÌý(Overseas Community Affairs Council, Republic of China)
• 3D Reconstruction of a Gastrulating Human EmbryoÌý(Cell)

Ìý

NeuralÌý

• The Vascular Contribution of Apolipoprotein E to Alzheimer’s DiseaseÌýÌý(Brain)
• The Role of Cellular Senescence in Neurodegenerative DiseasesÌýÌý(Archives Of Toxicology)
• Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post StrokeÌýÌý(Cell Death & Differentiation)
• Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical StressÌýÌý(Journal Of Cell Biology
• Cell Adhesion Molecule Signaling at the Synapse: Beyond the ScaffoldÌýÌý(Cold Spring Harbor Perspectives In Biology)
• Autism Patient-Derived SHANK2BY29X Mutation Affects the Development of ALDH1A1 Negative Dopamine NeuronÌýÌý(Molecular Psychiatry)
• New Perspective on Sustained Antidepressant Effect: Focus on Neurexins Regulating Synaptic PlasticityÌýÌý(Cell Death Discovery)
• Origin, Identity, and Function of Terminal Schwann CellsÌýÌý(Trends In Neurosciences)

Ìý

Cell TherapyÌý

• Global Effort Aims to Protect Health and Safety of Human ‘Guinea Pigs’ in Drug TrialsÌýÌý(Science Insider)
• RNA Aggregates Harness the Danger Response for Potent Cancer ImmunotherapyÌýÌý(Cell)
• Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human BrainÌýÌýOrganoids after TransplantationÌýÌý(Advanced Science)
• Promoting Alzheimer’s Disease Research and Therapy with Stem Cell TechnologyÌýÌý(Stem Cell Research & Therapy)
• Mechanism of Action, Potency and Efficacy: Considerations for Cell TherapiesÌýÌý(Journal Of Translational Medicine)
• Recent Trends in 3D Bioprinting Technology for Skeletal Muscle RegenerationÌýÌý(Acta Biomaterialia)
• GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor EfficacyÌýÌý(Molecular Therapy)
• First Fetus-to-Fetus Transplant Demonstrated in RatsÌý(Nature News)

Ìý

OrganoidÌý

• Pannexin1 Channel-Mediated Inflammation in Acute Ischemic StrokeÌýÌý(Aging and Disease)
• FinalSpark Launches the First Remote Research Platform Using Human Neurons for BiocomputingÌýÌý(FinalSpark (Businesswire))
• Establishment of Human Hematopoietic Organoids for Evaluation of Hematopoietic Injury and Regeneration EffectÌýÌý(Stem Cell Research & Therapy)
• First Model of the Brain’s Information Highways DevelopedÌýÌý(Informationsdienst Wissenschaft)Ìý
• Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue ReplenishmentÌýÌý(Nature Cell Biology)
• High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid ModelÌýÌý(BMC Molecular And Cell Biology)
• Sebaceous Gland Organoid EngineeringÌýÌý(Burns & Trauma)
• Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and ApplicationsÌýÌý(Signal Transduction And Targeted Therapy)

Ìý

April 2024

ESC and IPSCÌý

• A High Efficiency Precision Genome Editing Method with CRISPR in iPSCsÌýÌý(Scientific Reports)
• Development and Application of Haploid Embryonic Stem CellsÌýÌý(Stem Cell Research & Therapy)
• Human Embryonic Genetic Mosaicism and Its Effects on Development and DiseaseÌýÌý(Nature Genetics)
• Annelid Adult Cell Type Diversity and Their Pluripotent Cellular OriginsÌýÌý(Nature Communications)
• Reconstructing Axial Progenitor Field Dynamics in Mouse Stem Cell-Derived EmbryoidsÌýÌý(Developmental Cell)
• Crispr-Based Editing of Human Pluripotent Stem Cells for Disease ModelingÌýÌý(Stem Cell Reviews and Reports)
• Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature ReviewÌýÌý(Bioscience Reports)
• Scientists Made a Six-Legged Mouse Embryo — Here’s WhyÌýÌý(Nature)

Ìý

NeuralÌý

• Origin, Identity, and Function of Terminal Schwann CellsÌýÌý(Trends In Neurosciences)
• New Research Suggests Cerebellum May Play Important Role in AutismÌýÌýÌý(UC Davis Health)
• Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live NeuronsÌýÌý(Small)
• An Improved Method for Generating Human Spinal Cord Neural Stem CellsÌýÌý(Experimental Neurology)
• Neurofilaments as Biomarkers in Neurological Disorders — towards Clinical ApplicationÌýÌý(Nature Reviews Neurology)
• Autophagy and Exosomes; Inter-Connected Maestros in Alzheimer’s DiseaseÌýÌý(Inflammopharmacology)
• Immunological Aspects of Central NeurodegenerationÌý(Cell Discovery)
• The Endotoxin Hypothesis of Alzheimer’s DiseaseÌý(Molecular Neurodegeneration)

Ìý

Cell TherapyÌý

• First Fetus-to-Fetus Transplant Demonstrated in RatsÌý(Nature News)
• Cell Culture on Suspended Fiber for Tissue Regeneration: A ReviewÌýÌý(International Journal Of Biological Macromolecules)
• Expression and Processing of Mature Human Frataxin after Gene Therapy in MiceÌýÌý(Scientific Reports)
• This Startup Wants To Be OpenAI Of Stem Cell Therapy, Targets $250B MarketÌýÌý(Forbes)
• Mitochondrial DNA as a Target for Analyzing the Biodistribution of Cell Therapy ProductsÌýÌý(Scientific Reports)
• The Dual Role of Mesenchymal Stem Cells in Apoptosis RegulationÌýÌý(Cell Death & Disease)
• Xcell Biosciences Strengthens Cell and Gene Therapy Collaboration with LabcorpÌýÌý(Xcell Biosciences, Inc. (BusinessWire))

Ìý

OrganoidÌý

• Replacing Animal Testing With Stem Cell-Organoids: Advantages and LimitationsÌýÌý(Stem Cell Reviews And Reports)
• Antisense Oligonucleotide Therapeutic Approach for Timothy SyndromeÌýÌý(Nature)
• Generation of Human Cerebral Organoids with a Structured Outer Subventricular ZoneÌýÌý(Cell Reports)
• Advancing Organoid Engineering for Tissue Regeneration and Biofunctional ReconstructionÌýÌý(Biomaterials Research)
• Uncharted Territory: Ethical Questions Cloud Fetal Brain Organoid ResearchÌýÌý(Brain Tomorrow)
• Promising Preclinical Models for Lung Cancer Research—Lung Cancer Organoids: A Narrative ReviewÌýÌý(Translational Lung Cancer Research)
• Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with AxonsÌýÌý(Nature Communications)
• Generation of Human Cerebral Organoids with a Structured Outer Subventricular ZoneÌýÌý(Cell Reports)

Ìý

March 2024

ESC and IPSCÌý

• Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived NeurospheresÌýÌý(Regenerative Therapy)
• Stem Cell Models of Inherited ArrhythmiasÌýÌý(Nature Cardiovascular Research)
• iPSC-Derived Models for Anorexia Nervosa ResearchÌý(Trends in Molecular Medicine)
• Fetal Tissue Research Gains in Importance as Roadblocks MultiplyÌýÌý(STAT News)
• Crosstalk between Signaling Pathways and Energy Metabolism in PluripotencyÌýÌý(International Journal Of Stem Cells)
• Will These Reprogrammed Elephant Cells Ever Make a Mammoth?ÌýÌý(Nature)
• Embryonic Stem Cell Transplant Showing Safety in 12 PatientsÌýÌý(Parkinson’s News Today)

Ìý

NeuralÌý

• Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung InfectionÌýÌý(Cell)
• The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing ActÌýÌý(Journal Of Neurophysiology)
• Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’sÌýÌý(Science)
• Contrasting Somatic Mutation Patterns in Aging Human Neurons and OligodendrocytesÌýÌý(Cell)
• Updates on Mouse Models of Alzheimer’s DiseaseÌý(Molecular Neurodegeneration)
• Neuropathogenesis-on-Chips for Neurodegenerative DiseasesÌýÌý(Nature Communications)
• U of T Startup Targets Harmful Side Effect of Cancer TreatmentÌýÌý(University of Toronto)
• Computer scientist Wins NSF CAREER Award to Advance Alzheimer’s Research Using AIÌýÌý(Wake Forest University)
• Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain ClearanceÌýÌý(Nature)

Ìý

Cell TherapyÌý

• Nanomaterials Boost CAR-T Therapy for Solid TumorsÌý(Advanced Healthcare Materials)
• A Humanized Mouse Model for Adeno-Associated Viral Gene TherapyÌýÌý(Nature Communications)
• Why Is The FDA Concerned About Secondary Cancers After CAR T Cells?ÌýÌý(Forbes)
• Synthetic Receptor Scaffolds Significantly Affect the Efficiency of Cell Fate SignalsÌýÌý(Scientific Reports)
• Targeted Nonviral Delivery of Genome Editors In VivoÌý(Proceedings Of The National Academy Of Sciences Of The United States Of America)
• Emerging Strategies for Nanomedicine in AutoimmunityÌýÌý(Advanced Drug Delivery Reviews)
• Scripps Research Scientists Honored With Prestigious CZI Awards to Address Diseases Tied to AgingÌýÌý(Scripps Research)

Ìý

OrganoidÌý

• Past and Future of Alveolar Organoids for Lung Regenerative MedicineÌýÌý(Stem Cells)
• Advances and Applications of Cancer Organoids in Drug Screening and Personalized MedicineÌýÌý(Stem Cell Reviews And Reports)
• Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer PatientsÌýÌý(International Journal Of Cancer)
• Organ-on-Chip Models for Infectious Disease ResearchÌýÌý(Nature Microbiology)
• Cholangiocyte Organoids to Study Drug-Induced InjuryÌý(BMC)
• Bioengineering Toolkits for Potentiating Organoid TherapeuticsÌýÌý(Advanced Drug Delivery Reviews)
• Cellular Reprogramming as a Tool to Model Human Aging in a DishÌýÌý(Nature Communications)
• Vascularized Organoid-on-a-Chip: Design, Imaging, and AnalysisÌýÌý(Angiogenesis)

Ìý

February 2024

ESC and IPSCÌý

• Multiomics Evaluation of Human iPSCs and iPSC-Derived NeuronsÌýÌý(Journal Of Proteome Research)
• Cellular Reprogramming as a Tool to Model Human Aging in a DishÌýÌýÌý(Nature Communications)
• Epigenetic Reprogramming in the Transition from Pluripotency to TotipotencyÌýÌý(Journal of Cell Physiology)
• A Single-Cell Time-Lapse of Mouse Prenatal Development From Gastrula to BirthÌýÌý(Nature)
• Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart FailureÌýÌý(Journal Of Molecular And Cellular Cardiology)
• China Conducts First Nationwide Review of Retractions and Research MisconductÌýÌý(Nature News)
• Induced-Pluripotent Stem Cells and Neuroproteomics as Tools for Studying NeurodegenerationÌýÌý(Academic Radiology)
• Improving Stem Cell ResearchÌýÌý(Harvard University)

Ìý

NeuralÌý

• Multisensory Gamma Stimulation Promotes Glymphatic Clearance of AmyloidÌýÌý(Nature)
• Neuralink Brain Chip: Advance Sparks Safety and Secrecy ConcernsÌýÌý(Nature)
• GFAP-Isoforms in the Nervous System: Understanding the Need for DiversityÌýÌý(Current Opinion in Cell Biology)
• Dissecting the Spatiotemporal Diversity of Adult Neural Stem CellsÌýÌý(Molecular Systems Biology)
• New Rabies Viral Resources for Multi-Scale Neural Circuit MappingÌýÌý(Molecular Psychiatry)
• Identification of Direct Connections between the Dura and the BrainÌýÌý(Nature)
• 3D Printer Creates Brain Tissue That Acts like the Real ThingÌýÌý(Science)
• Mitochondrial Stress: A Key Role of Neuroinflammation in StrokeÌýÌý(Journal of Neuroinflammation)

Ìý

Cell TherapyÌý

• Gene Therapy in Glioblastoma Multiforme: Can It Be a Role Changer?ÌýÌý(Heliyon)
• Inibitory CARs Fail to Protect From Immediate T Cell CytotoxicityÌýÌý(Molecular Therapy)
• In ‘Major Milestone,’ FDA Approves First Cell Therapy for Solid TumorsÌýÌý(STAT News)
• Gene Therapy Allows a Deaf Child to Hear for the First TimeÌýÌý(Nature Italy)
• Host Brain Environmental Influences on Transplanted Medial Ganglionic Eminence ProgenitorsÌýÌý(Scientific Reports)
• Naturally Occurring T Cell Mutations Enhance Engineered T Cell TherapiesÌýÌý(Fractals-Complex Geometry Patterns And Scaling In Nature And Society)
• Roles of Exosomes in Immunotherapy for Solid CancersÌýÌý(Cell Death & Disease)

Ìý

OrganoidÌý

• The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth OrbitÌýÌý(Stem Cells And Development)
• Comparing Stem Cells, Transdifferentiation, and Brain Organoids as Tools for Psychiatric ResearchÌýÌý(Translational Psychiatry)
• Advanced Lung Organoids for Respiratory System and Pulmonary Disease ModelingÌýÌý(Journal of Tissue Engineering)
• A Growth Factor-Reduced Culture System for Colorectal Cancer OrganoidsÌýÌý(Cancer Letters)
• Chromatin Remodeling in Patient-Derived Colorectal Cancer ModelsÌýÌý(Advanced Science)
• Shaping the Neurovascular Unit Exploiting Human Brain OrganoidsÌýÌý(Molecular Neurobiology)
• Live Organoid Cyclic ImagingÌýÌý(Advanced Science)
• Characterizing Human Astrocyte Calcium Signaling in a Cerebral OrganoidÌýÌý(Biophysical Journal)

Ìý

January 2024

ESC &iPSC

• Hallmarks of Stemness in Mammalian Tissues (Cell Stem Cell)
• FOXO1-Mediated Lipid Metabolism Maintains Mammalian Embryos in Dormancy (Nature Cell Biology)
• DNA Methylation Restricts Coordinated Germline and Neural Fates in Embryonic Stem Cell Differentiation (Nature Structural & Molecular Biology)
• XIST Directly Regulates X-Linked and Autosomal Genes in Naive Human Pluripotent Cells (Cell)
• Mitotic Bookmarking Redundancy by Nuclear Receptors in Pluripotent Cells (Nature Structural & Molecular Biology)
• ROR2 Expression Predicts Human-Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GABAergic Neurons (Scientific Reports)
• Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts (Stem Cell Research)
• Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells (Cell Reports)
• Cloned Rhesus Monkey Lives to Adulthood for First Time (Nature News)
• Lineage Regulators TFAP2C and NR5A2 Function as Bipotency Activators in Totipotent Embryos (Nature Structural & Molecular Biology)
• ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1 (Developmental Cell)
• Telomere Dynamics in Human Pluripotent Stem Cells (Cell Cycle)
• The Impact of Induced Pluripotent Stem Cells in Animal Conservation (Veterinary Research Communications)

Neural

• SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab (ISS National Lab)
• Shigella Virulence Protein VirG Is a Broadly Protective Antigen and Vaccine Candidate (NPJ Vaccines)
• Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons (Nature Biotechnology)
• Human Cerebellar Organoids with Functional Purkinje Cells (Cell Stem Cell)
• The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer’s Disease (Scientific Reports)
• ÌýSynaptic-Like Transmission between Neural Axons and Arteriolar Smooth Muscle Cells Drives Cerebral Neurovascular Coupling (Nature Neuroscience)
• Yap/Taz Activity Is Associated with Increased Expression of Phosphoglycerate Dehydrogenase That Supports Myoblast Proliferation (Cell And Tissue Research)
• Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers (American Journal Of Physiology-Cell Physiology)
• Microglia Enhance Post-Anesthesia Neuronal Activity by Shielding Inhibitory Synapses (Nature Neuroscience)
• Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations (Tissue Engineering And Regenerative Medicine)
• Neocortical Neurogenesis in Development and Evolution—Human-Specific Features (Journal of Comparative Neurology)
• Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids (Cell Death Discovery)
• First Brain Organoids Grown from Fetal Tissue Offer Window on Development (Science)
• Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease (Science Advances)
• IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway (Cell Death & Disease)
• Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin (Journal Of Pathology)
• The Role of IL-6 in Neurodegenerative Disorders (Neurochemical Research)
• TREM2 Variants That Cause Early Dementia and Increase Alzheimer’s Disease Risk Affect Gene Splicing (Brain)
• DNA Methylation-Mediated Repression of microRNA-410 Promotes the Growth of Human Glioma Cells and Triggers Cell Apoptosis Through Its Interaction with STAT3 (Scientific Reports)
• SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence (Cell Stem Cell)
• Modeling the Neuroimmune System in Alzheimer’s and Parkinson’s Diseases (Journal of Neuroinflammation)

Organoid

• Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction (Biomicrofluidics)
• Human Apical-Out Nasal Organoids Reveal an Essential Role of Matrix Metalloproteinases in Airway Epithelial Differentiation (Nature Communications)
• High-Throughput Deconvolution of 3D Organoid Dynamics at Cellular Resolution for Cancer Pharmacology with Cellos (Nature Communications)
• Analysis of Off-Tumor Toxicities of T Cell-Engaging Bispecific Antibodies via Donor-Matched Intestinal Organoids and Tumoroids (Nature Biomedical Engineering)
• Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo (Cell Stem Cell)
• Spatiotemporal Modulation of Growth Factors Directs the Generation of Multilineage Mouse Embryonic Stem Cell-Derived Mammary Organoids (Developmental Cell)
• EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer (Cancer Cell)
• Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids (Science Of The Total Environment)
• Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids (Cell)
• Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations (Tissue Engineering And Regenerative Medicine)
• A Disulfidptosis-Related lncRNAs Signature in Hepatocellular Carcinoma: Prognostic Prediction, Tumor Immune Microenvironment and Drug Susceptibility (Scientific Reports)
• Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease (Cell Stem Cell)
• Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space’s Third Private Astronaut Mission (ISS National Laboratory)
• Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma (Molecular Cancer)
• In Vitro Models for Investigating Intestinal Host-Pathogen Interactions (Advanced Science)
• Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate (Biofabrication)
• Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation (Gut)
• Micro instrumentation for Brain Organoids (Advanced Healthcare Materials)
• Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers (Biofabrication)
• Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture (Biomacromolecules)
• Establishment of Tumor Microenvironment-Preserving Organoid Model from Patients with Intracranial Meningioma (Cancer Cell International)

Ìý

December 2023

Neural News

• The Neurobiology of SARS-CoV-2 InfectionÌý (Nature Reviews Neuroscience)
• Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient TreatmentsÌý (EMBO Molecular Medicine)
• Targeting Synapse Function and Loss for Treatment of Neurodegenerative DiseasesÌý (Nature Reviews Drug Discovery)
• White Matter Injury across Neurodegenerative DiseaseÌý (Trends In Neurosciences)
• Human-Specific Features and Developmental Dynamics of the Brain N-glycomeÌý (Science Advances)
• Efficient Generation of Brain Organoids Using Magnetized Gold NanoparticlesÌý (Scientific Reports)
• Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout MiceÌý (Neurochemical Research)
• Econazole Selectively Induces Cell Death in NF1-Homozygous Mutant Tumor CellsÌý (Cell Reports Medicine)

Organoid News

• Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient TreatmentsÌý (EMBO Molecular Medicine)
• A Rapid and Stable Spontaneous Reprogramming System of Spermatogonial Stem Cells to Pluripotent StateÌý (Cell & Bioscience)
• Efficient Generation of Brain Organoids Using Magnetized Gold NanoparticlesÌý (Scientific Reports)
• Applications of Lung Cancer Organoids in Precision Medicine: From Bench to BedsideÌý (Cell Communication and Signaling)
• The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived OrganoidsÌý (JCI Insight)
• In Vitro Modeling of the Human Dopaminergic System Using Spatially Arranged Ventral Midbrain–Striatum–Cortex AssembloidsÌý (Nature Methods)
• Single-Organoid Analysis Reveals Clinically Relevant Treatment-Resistant and Invasive Subclones in Pancreatic CancerÌý (NPJ Precision Oncology)
• 3D Hepatic Organoid Production from Human Pluripotent Stem CellsÌý (Differentiation)
• Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary CancerÌý (Cancer Letters)
• Adult Dental Epithelial Stem Cell-Derived Organoids Deposit Hydroxylapatite BiomineralÌý (International Journal of Oral Science)
• Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid FitnessÌý (Biofabrication)

Ìý

ESC & iPSC

• The Circadian Regulator PER1 Promotes Cell Reprogramming by Inhibiting Inflammatory Signaling From MacrophagesÌý (PLOS Biology)
• NAT10-Mediated ac4C Modification Promotes Ectoderm Differentiation of Human Embryonic Stem Cells via Acetylating NR2F1 mRNAÌý (Cell Proliferation)
• Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast DevelopmentÌý (Nature)
• Synthetic Genetic Circuits To Uncover the OCT4 Trajectories of Successful Reprogramming of Human FibroblastsÌý (Science Advances)
• A Human Embryonic Limb Cell Atlas Resolved in Space and TimeÌý (Nature)
• Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb LoopsÌý (Nature Communications)
• Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs)Ìý (Archives Of Toxicology)
• Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem CellsÌý (Stem Cells And Development)
• Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCsÌý (Biotechnology And Bioengineering)
• Utility of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells for Pharmacokinetic, Toxicological, and Immunological StudiesÌý (Biochemical And Biophysical Research Communications)
• A Patterned Human Primitive Heart Organoid Model Generated by Pluripotent Stem Cell Self-OrganizationÌý (Nature Communications)
• In Vitro Production of Naked Mole-Rats’ Blastocysts From Non-Breeding Females Using In Vitro Maturation and Intracytoplasmic Sperm InjectionÌý (Scientific Reports)

November 2023

ESC & iPSC News

• Metabolic Plasticity Sustains the Robustness of Caenorhabditis elegans Embryogenesis (EMBO Reports)
• The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells (Advanced Science)
• A Novel Perfusion Bioreactor Promotes the Expansion of Pluripotent Stem Cells in a 3D-Bioprinted Tissue Chamber (Biofabrication)
• NR5A2 Connects Zygotic Genome Activation to the First Lineage Segregation in Totipotent Embryo(Cell Research)
• Generation of Glucocorticoid-Producing Cells Derived from Human Pluripotent Stem Cells (Cell Reports Methods)
• Mammalian Oocytes Store Proteins for the Early Embryo on Cytoplasmic Lattices (Cell)
• Generation, Characterization, and Differentiation of Induced Pluripotent Stem-Like Cells in the Domestic Cat (Reproduction & Development)
• Small Molecule-Mediated Reprogramming of Xenopus Blastula Stem Cells to a Neural Crest State (Developmental Biology)
• This Hybrid Baby Monkey Is Made of Cells from Two Embryos (Nature)
• Single-Cell, Whole-Embryo Phenotyping of Mammalian Developmental Disorders (Nature)
• Generation of Induced Pluripotent Stem Cell Lines IRMBi003-A and IRMBi003-B from a Healthy Donor to Model Alzheimer’s Disease (Stem Cell Research)
• Generation of an NCS1 Gene Knockout Human Induced Pluripotent Stem Cell Line Using CRISPR/Cas9 (Stem Cell Research)
• Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract (Microbes And Infection)
• Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones (FEBS Open Bio)
• Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI (Stem Cell Research)

Cell Therapy News

• CAR T Cell Design-Dependent Remodeling of the Brain Tumor-Immune Microenvironment Modulates Tumor-Associated Macrophages and Anti-Glioma Activity (Cancer Research Communications)
• Implications of High Tumor Burden on Chimeric Antigen Receptor T Cell Immunotherapy (JAMA Oncology)
• Anti-TACI Single and Dual-Targeting CAR T Cells Overcome BCMA Antigen Loss in Multiple Myeloma (Nature Communications)
• CAR T Cells for Treating Autoimmune Diseases (RMD Open)
• Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures – a Multicentric, Randomized, Open Phase IIa Study (Stem Cells Translational Medicine)
• Genetic Retargeting of E3 Ligases to Enhance CAR T Cell Therapy (Cell Chemical Biology)
• An In Vitro Model of the Macrophage-Endothelial Interface to Characterize CAR T-cell Induced Cytokine Storm (Scientific Reports)
• Smart Nanoparticles for Cancer Therapy (Signal Transduction and Targeted Therapy)
• AT7867 Promotes Pancreatic Progenitor Differentiation of Human iPSCs (Stem Cell Reports)
• Transplanting Old Organs Promotes Senescence in Young Recipients (American Journal Of Transplantation)
• Injectable Supramolecular Hydrogels for In Situ Programming of CAR-T Cells towards Solid Tumor Immunotherapy (Advanced Materials)

Neural Cell News

• iPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer (Nature)
• Neuronal TIMP2 Regulates Hippocampus-Dependent Plasticity and Extracellular Matrix Complexity (Molecular Psychiatry)
• A Purkinje Cell to Parabrachial Nucleus Pathway Enables Broad Cerebellar Influence over the Forebrain (Nature Neuroscience)
• A Neurodegeneration Checkpoint Mediated by REST Protects against the Onset of Alzheimer’s Disease (Nature Communications)
• A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson’s Disease (Nature Medicine)
• Selective Plasticity of Fast and Slow Excitatory Synapses on Somatostatin Interneurons in Adult Visual Cortex (Nature Communications)
• Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson’s Disease (Molecular Neurodegeneration)
• STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges (Neuron)
• Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures (Brain Behavior And Immunity)
• The Circadian Clock Time Tunes Axonal Regeneration (Cell Metabolism)
• Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy (Nature Communications)
• Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model (Nature Communications)
• Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition (Nature Communications)
• Molecular Biomarkers for Vascular Cognitive Impairment and Dementia (Nature Reviews Neurology)
• Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy (Proceedings Of The National Academy Of Sciences Of The United States Of America)
• Characterization of Neuromuscular Transmission and Projections of Muscle Motor Neurons in the Rat Stomach (American Journal Of Physiology-Gastrointestinal And Liver Physiology)
• Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids (Frontiers In Neuroscience)
• Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem (Nature)
• Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency (Cell Reports Methods)
• Disruption of the Autism Gene and Chromatin Regulator KDM5A Alters Hippocampal Cell Identity (Science Advances)

Organoid Cell News

• The Drug Efficacy Testing in 3D Cultures Platform Identifies Effective Drugs for Ovarian Cancer Patients (NPJ Precision Oncology)
• Using Picoliter Droplet Deposition to Track Clonal Competition in Adherent and Organoid Cancer Cell Cultures (Scientific Reports)
• Cancer-on-Chip Models for Metastasis: Importance of the Tumor Microenvironment (Trends In Biotechnology)
• SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs (Experimental & Molecular Medicine)
• In-Organoid Single-Cell CRISPR Screening Reveals Determinants of Hepatocyte Differentiation and Maturation (Genome Biology)
• Potential Application of Intestinal Organoids in Intestinal Diseases (Stem Cell Reviews and Reports)
• Ascorbate Protects Human Kidney Organoids From Damage Induced by Cell-Free Hemoglobin (Disease Models & Mechanisms)
• Hepatitis C Virus Infects and Perturbs Liver Stem Cells (mBio)
• Patient-Derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer (npj Precision Oncology)
• Reconstruction of Dynamic Mammary Mini Gland In Vitro for Normal Physiology and Oncogenesis (Nature Methods)
• Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation (Journal Of Clinical Investigation)
• Cochlear Organoids Reveal Transcriptional Programs of Postnatal Hair Cell Differentiation from Supporting Cells (Cell Reports)
• Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture (Biofabrication)
• Recent Advances in Lung Organoid Development and Applications in Disease Modeling (Journal Of Clinical Investigation)
• Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease (EMBO Journal)
• Human Intestinal Organoids: Modeling Gastrointestinal Physiology and Immunopathology – Current Applications and Limitations (European Journal Of Immunology)
• Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication)
• Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery (Advanced Materials)
• Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells (Stem Cell Reports)
• NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation (Development)
• Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects (Cell)

OctoberÌý2023

• The Role of Zfp352 in the Regulation of Transient Expression of 2-Cell Specific Genes in Mouse Embryonic Stem Cells (Genes to Cells)
• Telomeric DNA Breaks in Human Induced Pluripotent Stem Cells Trigger ATR-Mediated Arrest and Telomerase-Independent Telomere Damage RepairÌýÌý (Journal of Molecular Cell Biology)
• Transcriptomic Analysis of PADI4 Target Genes during Multi-Lineage Differentiation of Embryonic Stem CellsÌýÌý(Philosophical Transactions Of The Royal Society B-Biological Sciences)
• The Efficient Generation of Functional Human Hepatocytes from Chemically Induced Pluripotent Stem Cells (Cell Proliferation)
• Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation TechniqueÌý (Biomedical Materials)
• Functional Interrogation of Twenty Type 2 Diabetes-Associated Genes Using Isogenic Human Embryonic Stem Cell-Derived β-Like Cells (Cell Metabolism)
• BRD9-Mediated Control of the TGF-β/Activin/Nodal Pathway Regulates Self-Renewal and Differentiation of Human Embryonic Stem Cells and Progression of Cancer Cells (Nucleic Acids Research)
• Investigation of Immune-Related Diseases Using Patient-Derived Induced Pluripotent Stem Cells(Inflammation and Regeneration)

Cell Therapy News

• A Deregulated m6A Writer Complex Axis Driven by BRD4 Confers an Epitranscriptomic Vulnerability in Combined DNA Repair–Targeted Therapy (Proceedings Of The National Academy Of Sciences Of The United States Of America)
• Preclinical Development of a Chimeric Antigen Receptor T Cell Therapy Targeting FGFR4 in Rhabdomyosarcoma (Cell Reports Medicine)
• Involving Stemness Factors to Improve CAR T-Cell-Based Cancer Immunotherapy (Medical Oncology)
• Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells (ACS Nano)
• Sustained Long-Term Disease Correction in a Murine Model of MPSII Following Stem Cell Gene Therapy (Molecular Therapy-Methods & Clinical Development)
• Mind the GAP: RASA2 and RASA3 GTPase-Activating Proteins As Gatekeepers of T Cell Activation and Adhesion (Trends in Immunology)
• Synthetic Transcription Factor Engineering for Cell and Gene Therapy (Trends In Biotechnology)
• NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease (NKGen Biotech Inc.)

Neural News

• Fe65-Engineered Neuronal Exosomes Encapsulating Corynoxine-B Ameliorate Cognition and Pathology of Alzheimer’s Disease (Signal Transduction and Targeted Therapy)
• Clinical Trial Links Oncolytic Immunoactivation to Survival in Glioblastoma (Nature)
• Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis (Nature Cell Biology)
• A Humanized Chemogenetic System Inhibits Murine Pain-Related Behavior and Hyperactivity in Human Sensory Neurons (Science Translational Medicine)
• Models for Evaluating Glioblastoma Invasion along White Matter Tracts (Trends in Biotechnology)
• Subventricular Zone Cytogenesis Provides Trophic Support for Neural Repair in a Mouse Model of Stroke (Nature Communications)
• Microglia and Complement Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease (Nature Medicine)
• This Is the Largest Map of the Human Brain Ever Made (Nature)
• HMGA2 Directly Mediates Chromatin Condensation in Association with Neuronal Fate Regulation (Nature Communications)
• Dexmedetomidine Alleviates Cognitive Impairment by Promoting Hippocampal Neurogenesis via BDNF/TrkB/CREB Signaling Pathway in Hypoxic–Ischemic Neonatal Rats (CNS Neuroscience & Therapeutics)

Organoid News

• Establishment of a 96-Well Transwell System Using Primary Human Gut Organoids to Capture Multiple Quantitative Pathway Readouts (Scientific Reports)
• Efficient Genetic Editing of Human Intestinal Organoids Using Ribonucleoprotein-Based CRISPR (Disease Models & Mechanisms)
• Mapping Oto-Pharyngeal Development in a Human Inner Ear Organoid Model (Development) ÌýA Scalable Human Islet 3D-Culture Platform Maintains Cell Mass and Function Long-Term for Transplantation (American Journal Of Transplantation)
• Tissue Morphology Influences the Temporal Program of Human Brain Organoid Development (Cell Stem Cell)
• Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1^KO and CRB1^KOCRB2^+/- Retinal Organoids (Molecular Therapy-Methods & Clinical Development)
• Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency (eLife)
• Unlocking the Potential of Organoids in Cancer Treatment and Translational Research: An Application of Cytologic Techniques (Cancer Cytopathology)
• Induced Regeneration of Articular Cartilage: Identification of a Dormant Regeneration Program for a Non-regenerative Tissue Icon for the Forest of Biologists (Development)
• Systematic Review: Predictive Value of Organoids in Colorectal CancerÌý(Scientific Reports)

Ìý

September 2023

• GATA1 Deletion in Human Pluripotent Stem Cells Increases Differentiation Yield and Maturity of Neutrophils (iScience)
• CHK1-CDC25A-CDK1 Regulate Cell Cycle Progression and Protect Genome Integrity in Early Mouse Embryos (EMBO Reports)
• Recent Advances in Regulating the Proliferation or Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Stem Cell Research & Therapy)
• Comparison of miRNA Transcriptome of Exosomes in Three Categories of Somatic Cells with Derived iPSCs (Scientific Data)
• Directed Differentiation of Human Pluripotent Stem Cells into Articular Cartilage Reveals Effects Caused by Absence of WISP3, the Gene Responsible for Progressive Pseudorheumatoid Arthropathy of ChildhoodÌý (Cytotherapy)
• Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells (CRISPR Journal)
• KLF4 Facilitates Chromatin Accessibility Remodeling in Porcine Early Embryos (Science China Life Sciences)
• DUX4 Expression in Cancer Induces a Metastable Early Embryonic Totipotent Program (Cell Reports)
• Uncovering the Role of FOXA2 in the Development of Human Serotonin Neurons (Advanced Science)
• Human Trials of Artificial Wombs Could Start Soon. Here’s What You Need to Know (Nature News)
• Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels (Frontiers in Physiology)
• Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development (Journal of Neural Engineering)
• Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics (Frontiers in Neuroscience)
• Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells (Molecular Therapy-Methods & Clinical Development)
• Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification (Nature Communications)
• Induced Pluripotent Stem Cells: Ex Vivo Models for Human Diseases Due to Mitochondrial DNA Mutations (Journal of Biomedical Science)
• TOBF1 Modulates Mouse Embryonic Stem Cell Fate through Regulating Alternative Splicing of Pluripotency Genes (Cell Reports)

Ìý

August 2023

• Manipulating and Studying Gene Function in Human Pluripotent Stem Cell Models (FEBS Letters)
• Rat Post-Implantation Epiblast-Derived Pluripotent Stem Cells Produce Functional Germ Cells (Cell Reports Methods)
• NAT10-Mediated N4-Acetylcytidine mRNA Modification Regulates Self-Renewal in Human Embryonic Stem Cells (Nucleic Acids Research)
• Country-Specific Regulation and International Standardization of Cell-Based Therapeutic Products Derived from Pluripotent Stem Cells (Stem Cell Reports)
• Female Naïve Human Pluripotent Stem Cells Carry X Chromosomes with Xa-Like and Xi-Like Folding Conformations (Science Advances)
• A Fast Chemical Reprogramming System Promotes Cell Identity Transition through a Diapause-Like State (Nature Cell Biology)
• Distinct Characteristics of Two Types of Alternative Lengthening of Telomeres in Mouse Embryonic Stem Cells (Nucleic Acids Research)
• The MORC2 p.S87L Mutation Reduces Proliferation of Pluripotent Stem Cells Derived from a Patient with the Spinal Muscular Atrophy-Like Phenotype by Inhibiting Proliferation-Related Signaling Pathways (Journal Of Immunotherapy)
• Utilizing Human Induced Pluripotent Stem Cells to Study Atrial Arrhythmias in the Short QT Syndrome (Journal Of Molecular And Cellular Cardiology)
• Reprogramming iPSCs to Study Age-Related Diseases: Models, Therapeutics, and Clinical Trials (Mechanisms Of Ageing And Development)
• Cell-Type-Specific Regulation of APOE and CLU Levels in Human Neurons by the Alzheimer’s Disease Risk Gene SORL1 (Cell Reports)
• Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway (Tissue Engineering And Regenerative Medicine)
• Control of Stem Cell Renewal and Fate by YAP and TAZ (Nature Reviews Molecular Cell Biology)
• Haspin Balances the Ratio of Asymmetric Cell Division Through Wnt5a and Regulates Cell Fate Decisions in Mouse Embryonic Stem Cells (Cell Death Discovery)
• Effects of Low Doses of Methylmercury (MeHg) Exposure on Definitive Endoderm Cell Differentiation in Human Embryonic Stem Cells (Archives Of Toxicology)
• Improved Cryopreservation of Human Induced Pluripotent Stem Cell (iPSC) and iPSC Derived Neurons Using Ice-Recrystallization Inhibitors (Stem Cells)
• Wnt and BMP Signaling Direct Anterior/Posterior Differentiation in Aggregates of Mouse Embryonic Stem Cells (Biology Open)
• The Induction of Parathyroid Cell Differentiation from Human Induced Pluripotent Stem Cells Promoted via TGF-α/EGFR Signaling (Stem Cells And Development)
• Single-Molecule Tracking of Nanog and Oct4 in Living Mouse Embryonic Stem Cells Uncovers a Feedback Mechanism of Pluripotency Maintenance (EMBO Journal)

Ìý

July 2023

• Building Human Artery and Vein Endothelial Cells from Pluripotent Stem Cells, and Enduring Mysteries Surrounding Arteriovenous Development (Seminars in Cell & Developmental Biology)
• Derivation and Characteristics of Induced Pluripotent Stem Cells from a Patient with Acute Myelitis (Frontiers In Cell And Developmental Biology)
• Chemical Genomics Reveals Targetable Programs of Human Cancers Rooted in Pluripotency (Cell Chemical Biology)
• ZMYM2 Is Essential for Methylation of Germline Genes and Active Transposons in Embryonic Development (Nucleic Acids Research)
• Artificial Induction of Circadian Rhythm by Combining Exogenous BMAL1 Expression and Polycomb Repressive Complex 2 Inhibition in Human Induced Pluripotent Stem Cells (Cellular and Molecular Life Sciences)
• Effective SARS-CoV-2 Replication of Monolayers of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells (Scientific Reports)
• Human Trophoblast Stem Cell-State Acquisition from Pluripotent Stem Cells and Somatic Cells (Current Opinion in Genetics & Development)
• Restricting Epigenetic Activity Promotes the Reprogramming of Transformed Cells to Pluripotency in a Line-Specific Manner (Cell Death Discovery)
• Crosstalk between RNA m6A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells (Nature Genetics)

June 2023

• Pluripotency-Independent Induction of Human Trophoblast Stem Cells from FibroblastsÌý(Nature Communications)Ìý
• Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture MicroenvironmentÌý(Frontiers In Oncology)Ìý
• LIS1 RNA-Binding Orchestrates the Mechanosensitive Properties of Embryonic Stem Cells in AGO2-Dependent and Independent WaysÌý(Nature Communications)Ìý
• Identification and Functional Evaluation of Alternative Splice Variants of Dax1 in Mouse Embryonic Stem CellsÌý(Stem Cells And Development)Ìý
• The Circadian Clock CRY1 Regulates Pluripotent Stem Cell Identity and Somatic Cell ReprogrammingÌý(Cell Reports)Ìý
• On-Chip Real-Time Impedance Monitoring of hiPSC-Derived and Artificial Basement Membrane-Supported EndotheliumÌý(Bioactive Materials)
• Suspension Culture Improves iPSC Expansion and Pluripotency PhenotypeÌý(Current Stem Cell Research & Therapy)Ìý
• Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse EmbryoÌý(Nature Communications)Ìý
• Pluripotency-Independent Induction of Human Trophoblast Stem Cells from FibroblastsÌý(Nature Communications)Ìý
• Harnessing Three-Dimensional (3D) Cell Culture Models for Pulmonary Infections: State of the Art and Future DirectionsÌý(Naunyn-Schmiedebergs Archives Of Pharmacology)Ìý
• Generation of an Induced Pluripotent Stem Cell Lines NSHDMUi001-A from Patients with Type 2 DiabetesÌý(Stem Cell Research)
• GSK-3α/β and MEK Inhibitors Assist the Microenvironment of Tumor InitiationÌý(Cytotechnology)
• A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem CellsÌý(Nature)Ìý
• Self-Patterning of Human Stem Cells into Post-implantation LineagesÌý(Nature)ÌýÌý
• Most Advanced Synthetic Human Embryos Yet Spark ControversyÌý(Nature News)Ìý
• Sequential and Directional Insulation by Conserved CTCF Sites Underlies the Hox Timer in StembryosÌý(Nature Genetics)Ìý
• Cell-Membrane-Coated and Cell-Penetrating Peptide-Conjugated Trimagnetic Nanoparticles for Targeted Magnetic Hyperthermia of Prostate Cancer Cells [ACS Applied Materials & Interfaces]Ìý
• Comparative Landscape of Genetic Dependencies in Human and Chimpanzee Stem CellsÌý(Cell)Ìý
• Overcoming the H4K20me3 Epigenetic Barrier Improves Somatic Cell Nuclear Transfer Reprogramming Efficiency in MiceÌý(Cell Proliferation)Ìý
• Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like CellsÌý(Stem Cell Reviews And Reports)ÌýÌý
• An O-GlcNAc Transferase Pathogenic Variant Linked to Intellectual Disability Affects Pluripotent Stem Cell Self-RenewalÌý(Disease Models & Mechanisms)Ìý
• Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson’s Disease Patients Carrying the Heterozygous Mutations c.815G > a (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1Ìý)Stem Cell Research)Ìý
• Generation of Induced Pluripotent Stem Cell Line (XWHNi002-a) from a Female with APP Gene Mutation (Stem Cell Research)Ìý
• Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced NeuronsÌý(Cellular Reprogramming)Ìý
• Human Prostate Organoid Generation and the Identification of Prostate Development Drivers Using Inductive Rodent TissuesÌý(Development)Ìý
• A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells (Nature)Ìý
• Self-Patterning of Human Stem Cells into Post-implantation Lineages (Nature)Ìý

Ìý

Ìý

May 2023

• Identification of an Adipose Tissue-Resident Pro-Preadipocyte PopulationÌý(Cell Reports)Ìý
• Optogenetic Manipulation Identifies the Roles of ERK and AKT Dynamics in Controlling Mouse Embryonic Stem Cell Exit from PluripotencyÌý(Developmental Cell)Ìý
• Human Embryo Science: Can the World’s Regulators Keep Pace?(Nature News)Ìý
• Esrrb Guides Naive Pluripotent Cells through the Formative Transcriptional ProgrammeÌý(Nature Cell Biology)Ìý
• Acoel Single-Cell Atlas Reveals Expression Dynamics and Heterogeneity of Adult Pluripotent Stem CellsÌý(Nature Communications)Ìý
• Hypo immune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus MacaquesÌý
• (Nature Biotechnology)Ìýhttps://www.nature.com/articles/s41587-023-01784-x
• Embryonic Stem Cell ERK, AKT, Plus STAT3 Response Dynamics Combinatorics Are Heterogeneous but NANOG State IndependentÌý(Stem Cell Reports)Ìý
• Generation of iPSC-Derived Human Forebrain Organoids Assembling Bilateral Eye PrimordiaÌý(Nature Protocols)Ìý
• A CRISPR-Engineered Isogenic Model of the 22q11.2 A-B Syndromic DeletionÌý(Scientific Reports)Ìý
• Cellular Population Dynamics Shape the Route to Human PluripotencyÌý
• (Nature Communications)Ìýhttps://www.nature.com/articles/s41467-023-37270-w
• The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human Induced Pluripotent Stem Cell-Derived Enterocyte-Like CellsÌý(Stem Cells)Ìý
• RNA Stability Controlled by m6A Methylation Contributes to X-to-Autosome Dosage Compensation in MammalsÌý(Nature Structural & Molecular Biology)Ìý
• Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse EmbryoÌý(Nature Communications)Ìý
• Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell ReplacementÌý(Stem Cells Translational Medicine)ÌýÌý
• Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem CellsÌý(Cell Discovery)Ìý
• USP7 Represses Lineage Differentiation Genes in Mouse Embryonic Stem Cells by Both Catalytic and Noncatalytic ActivitiesÌý(Science Advances)Ìý
• Extensive Programmed Centriole Elimination Unveiled inÌýC. elegansÌýEmbryosÌý(Science Advances)Ìý
• Ablation of ZC3H11A Causes Early Embryonic Lethality and Dysregulation of Metabolic ProcessesÌý
• [Proceedings Of The National Academy Of Sciences Of The United States Of America]Ìý
• Reprogramming of Three-Dimensional Chromatin Organization in the Early EmbryoÌý
• (Current Opinion In Structural Biology)Ìý
• Mesodermal FGF and BMP Govern the Sequential Stages of Zebrafish Thyroid SpecificationÌý(Development)Ìý
• Differentiation and Single-Cell RNA-Seq Analyses of Human Pluripotent-Stem-Cell-Derived Renal OrganoidsÌý(Star Protocols)Ìý
• The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem CellsÌý(CRISPRÌýJournal)https://www.liebertpub.com/doi/10.1089/crispr.2023.0013
• First Female Arab Astronaut Reaches ISS for Historic Mission to Conduct Stem Cell & Cancer ResearchÌý(The Free Press Journal)Ìý
• Is Space the Place for Stem Cell Manufacturing? Scientists Will Soon Test That on the ISSÌý(FierceBiotech)Ìý
• Modulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation during Human iPSC DifferentiationÌý(Stem Cells)Ìý
• MutSα and MutSβ as Size-Dependent Cellular Determinants for Prime Editing in Human Embryonic Stem CellsÌý(Molecular Therapy – Nucleic Acids)Ìý
• Generation of Stable Integration-Free Pig Induced Pluripotent Stem Cells under Chemically Defined Culture ConditionÌý(Cell Proliferation)Ìý
• Parallel Genome-Wide CRISPR Screens to Identify State-Dependent Self-Renewal Regulators of Mouse Embryonic Stem CellsÌý(Stem Cells and Development)Ìý
• CRISPR/Cas9 Assisted Stem Cell Therapy in Parkinson’s DiseaseÌý(Biomaterials Research)Ìý
• The RNA Cap Methyltransferases RNMT and CMTR1 Co-Ordinate Gene Expression during Neural DifferentiationÌý(Biochemical Society Transactions)Ìý
• BCL2 Is a Major Regulator of Haploidy Maintenance in Murine Embryonic Stem CellsÌý(Cell Proliferation)
• Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral NeuropathyÌý(Cell Stem Cell)
• Establishment of Bovine Trophoblast Stem Cells (Cell Report)
• (23)00450-3
• Chemically Defined Production of Tri-Lineage Human iPSC-Derived Cardiac SpheroidsÌý(Current Protocols)Ìý
• Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture SystemÌý(Cell Reports Methods)Ìý
• A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem CellsÌý(Endocrine Connections)Ìý\
• Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A VariantsÌý(Philosophical Transactions Of The Royal Society B-Biological Sciences)Ìý
• The Generation and Properties of Human Cortical Organoids as a Disease Model for Malformations of Cortical DevelopmentÌý(Neural Regeneration Research)Ìý
• Efficient and Rapid Fluorescent Protein Knock-In with Universal Donors in Mouse Embryonic Stem CellsÌý(Development)Ìý
• A Desert lncRNA HIDEN Regulates Human Endoderm Differentiation via Interacting with IMP1 and Stabilizing FZD5 mRNAÌý(Genome Biology)
• Modeling Human Skeletal Development Using Human Pluripotent Stem CellsÌý
• (Proceedings Of The National Academy Of Sciences Of The United States Of America)Ìý

Ìý

April 2023

• A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation inÌýHTRA1Ìý(Inflammation and Regeneration)Ìý
• Development of substrates for the culture of human pluripotent stem cellsÌý(Biomaterials Science)Ìý
• Albumin-Based Solution Is the Ideal Post-thawing Suspension Medium for Cord Blood Hematopoietic Stem Cells: A Stability and Proliferative EvaluationÌý(Transfusion)Ìý
• Brain p3-Alcβ Peptide Restores Neuronal Viability Impaired by Alzheimer’s Amyloid β-PeptideÌý(EMBO Molecular Medicine)Ìý
• Extracellular Vesicles in Tumor Angiogenesis and Resistance to Anti-Angiogenic TherapyÌý(Cancer Science)Ìý
• Gene Editing to Prevent Ventricular Arrhythmias Associated with Cardiomyocyte Cell TherapyÌý(Cell Stem Cell)Ìý
• Hematopoietic Stem-Cell Gene Therapy Is Associated with Restored White Matter Microvascular Function in Cerebral AdrenoleukodystrophyÌý(Nature Communications)Ìý
• Interleukin-1 Receptor Antagonist: A Promising Cytokine against Human Squamous Cell CarcinomasÌý(Heliyon)Ìý
• Modelling Hyperexcitability in Human Cerebral Cortical Organoids: Oxygen/Glucose Deprivation Most Effective StimulantÌý(Heliyon)Ìý
• Pluripotent, Germ Cell Competent Adult Stem Cells Underlie Cnidarian Regenerative Ability and Clonal GrowthÌý(Current Biology)Ìý
• Rif1ÌýRegulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem CellsÌý(Stem Cell Reviews and Reports)Ìý
• Scalable generation of sensory neurons from human pluripotent stem cellsÌý(STEM CELL REPORTS)Ìý
• Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cellsÌý(STEM CELL REPORTS)Ìý
• Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorderÌý(Molecular Psychiatry)Ìý
• A hydrogel model of the human blood-brain barrier using differentiated stem cellsÌý(PLOS ONE)Ìý
• Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell DifferentiationÌý(ACS Nano)Ìý
• Induced pluripotent stem cell technology in bone biologyÌý(Science Direct)Ìý
• Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytesÌý(Cell Reports)Ìý
• Engineering Alignment Has Mixed Effects on Human Induced Pluripotent Stem Cell Differentiated Cardiomyocyte MaturationÌý(Tissue Engineering Part A)Ìý
• Secretive Derived from Hypoxia Preconditioned Mesenchymal Stem Cells Promote Cartilage Regeneration and Mitigate Joint Inflammation via Extracellular VesiclesÌý(Bioactive Materials)Ìý
• Skeletal Muscle Gene Expression Dysregulation in Long-Term Spaceflights and Aging Is Clock-DependentÌý(NPJ Microgravity)Ìý

• Advancing Cell Therapy for Neurodegenerative DiseasesÌý(Cell Stem Cell)Ìý

• A Multi-Omics Integrative Analysis Based on CRISPR Screens Re-defines the Pluripotency Regulatory Network in ESCsÌý(Communications Biology)Ìý
• Cancer Neuroscience: State of the Field, Emerging DirectionsÌý(Cell)Ìý
• CRISPR-Based Functional Genomics Screening in Human-Pluripotent-Stem-Cell-Derived Cell Types(Cell Genomics)Ìý
• DC Vaccine Enhances CAR-T Cell Antitumor Activity by Overcoming T Cell Exhaustion and Promoting T Cell Infiltration in Solid TumorsÌý(Clinical And Translational Oncology)Ìý
• Decoding the Molecular Crosstalk between Grafted Stem Cells and the Stroke-Injured BrainÌý(Cell Reports)Ìý
• Human iPSC-Derived Neural Progenitor Cells Secreting GDNF Provide Protection in Rodent Models of ALS and Retinal DegenerationÌý(Stem Cell Reports)Ìý
• MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4Ìý(Current Medical Science)
• Mechanisms of Resistance and Treatment of Relapse After CAR T-Cell Therapy for Large B-Cell Lymphoma and Multiple MyelomaÌý(Transplantation And Cellular Therapy)
• Progress and Emerging Techniques for Biomaterial-Based Derivation of Mesenchymal Stem Cells (MSCs) from Pluripotent Stem Cells (PSCs)Ìý(Biomaterials Research)
• Transforming the Understanding of Brain ImmunityÌý(Science)
• AnÌýIn VivoÌýNeuroimmune Organoid Model to Study Human Microglia Phenotypes (Cell)
• Directing iPSC Differentiation into iTenocytes Using Combined Scleraxis Overexpression and Cyclic Loading (Journal of Orthopaedic Research)
• Autologous Mesenchymal Stem Cells Offer a New Paradigm for Salivary Gland Regeneration (International Journal of Oral Science)
• Hypoimmune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques (Nature Biotechnology)
• Rescue of GM3 Synthase Deficiency by Spatially Controlled, rAAV-MediatedÌýST3GAL5ÌýDelivery (JCI Insight)
• Effects of HDAC Inhibitors on Neuroblastoma SH-SY5Y Cell Differentiation Into Mature Neurons via the Wnt Signaling Pathway (BMC Neuroscience)
• Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy (Cell Stem Cell)
• Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System (Cell Reports Methods)
• A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells (Endocrine connections)
• Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca²⁺-Homeostasis in Clinical Arrhythmia Associated with Combined HeterozygousÌýRYR2ÌýandÌýSCN10AÌýVariants (Philosophical Transactions Of The Royal Society B-Biological Sciences)
• Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect against Abdominal Aortic Aneurysm Formation by Inhibiting NET-Induced Ferroptosis (Communications Biology)
• Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells (Cell Discovery)

Ìý

March 2023

• Dipeptidyl peptidase 4 Promotes Survival and Stemness of Acute Myeloid Leukemia Stem CellsÌý(Cell Reports)Ìý
• Generation of Self-Organized Autonomic Ganglion Organoids from FibroblastsÌý(iScience)Ìý
• Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable VulnerabilitiesÌý(Leukemia)Ìý
• Melatonin-Mediated FKBP4 Downregulation Protects against Stress-Induced Neuronal Mitochondria Dysfunctions by Blocking Nuclear Translocation of GRÌý(Cell Death & Disease)Ìý
• Patient-Derived Spheroids and Patient-Derived Organoids Simulate Evolutions of Lung CancerÌý(Heliyon)Ìý
• Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A ReceptorsÌý(Science)Ìý

• A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 InfectionÌý(Nature Cell Biology)Ìý
• Apoptosis Inhibition Enhances Induced Pluripotent Stem Cell Generation during T Cell ReprogrammingÌý(Biochemical and Biophysical Research Communications)Ìý
• Clinical Use of CAR T-cells in Treating Acute Lymphoblastic LeukemiaÌý(Transfusion And Apheresis Science)Ìý
• Dying Transplanted Neural Stem Cells Mediate Survival Bystander Effects in the Injured BrainÌý(Cell Death & Disease)Ìý
• Fibroblast Heterogeneity: Keystone of Tissue Homeostasis and Pathology in Inflammation and AgingÌý(Frontiers In Immunology)Ìý
• Generation of Functional Oocytes from Male MiceÌýIn VitroÌý(Nature)Ìý
• Highly Efficient and Rapid Generation of Human Pluripotent Stem Cells by Chemical ReprogrammingÌý(Cell Stem Cell)Ìý
• Improved Survival of Patients with Primary Plasma Cell Leukemia with VRd or Daratumumab-based Quadruplets: A Multicenter Study by the Greek Myeloma Study GroupÌý(American Journal Of Hematology)
• Implantation of Engineered Human Microvasculature to Study Human Infectious Diseases in Mouse ModelsÌý(iScience)Ìý
• The Novel GATA1-Interacting Protein HES6 Is an Essential Transcriptional Cofactor for Human ErythropoiesisÌý(Nucleic Acids Research)Ìý
• Very Small Embryonic-Like Stem Cells Transform into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood TestÌý(Stem Cells)

Ìý

February 2023

• A Molecular Characterization and Clinical Relevance of Microglia-Like Cells Derived from Patients with Panic DisorderÌý(Translational Psychiatry)Ìý
• Bioengineering Approaches to Promote Maturity in Human Skeletal Muscle ConstructsÌý(Biophysical Journal)Ìý
• Cancer Stem Cells: Recent Insights and TherapiesÌý(Biochemical Pharmacology)Ìý
• Supports Meso-Endoderm Differentiation from Mouse Embryonic Stem CellsÌý(Nature Communications)Ìý
• Inflammation and DNA Damage: Cause, Effect or BothÌý(Nature Reviews Rheumatology)Ìý
• iPSC-Based Modeling of THD Recapitulates Disease Phenotypes and Reveals Neuronal MalformationÌý(EMBO Molecular Medicine)Ìý
• Lnc956-TRIM28-HSP90B1 Complex on Replication Forks Promotes CMG Helicase Retention to Ensure Stem Cell Genomic Stability and EmbryogenesisÌý(Science Advances)Ìý
• Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical TrialsÌý(Transplantation And Cellular Therapy)Ìý
• NANOGP1, a Tandem Duplicate of NANOG, Exhibits Partial Functional Conservation in Human Naïve Pluripotent Stem CellsÌý(Development)Ìý
• Nanosheet Coating Improves Stability of Human Pluripotent Stem Cell Culture on Glass SubstratesÌý(Biochemical and Biophysical Research Communications)Ìý
• Reversal of Aging-Associated Increase in Myelopoiesis and Expression of Alarmins by Angiotensin-(1–7)Ìý(Scientific Reports)Ìý
• Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche EnvironmentÌý(Nature Communications)Ìý
• Transgenic Skin Biomechanical Properties Following First Lifesaving Epidermal Regeneration Using Combined Gene and Cell TherapyÌý(Journal of the German Society of Dermatology)Ìý

Ìý

January 2023

• Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and ProspectsÌý(Tissue and Cell)Ìý
• Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1Ìý(ACS Nano)Ìý
• Corneal Stem Cells Niche and Homeostasis Impacts in Regenerative Medicine; Concise ReviewÌý(European Journal of Ophthalmology)Ìý
• Cross-Species Transcriptomic Atlas of Dorsal Root Ganglia Reveals Species-Specific Programs for Sensory FunctionÌý(Nature Communications)Ìý
• Endothelial Cell-Derived Exosomes Boost and Maintain Repair-Related Phenotypes of Schwann Cells via miR199-5p to Promote Nerve RegenerationÌý(Journal Of Nanobiotechnology)Ìý
• Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down SyndromeÌý(Stem Cell Reviews and Reports)Ìý
• Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical PotentialÌý(Molecular Therapy-Methods & Clinical Development)Ìý
• Photoreceptor Laminin Drives Differentiation of Human Pluripotent Stem Cells to Photoreceptor Progenitors That Partially Restore Retina FunctionÌý(Molecular Therapy)Ìý
• Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle RegressionÌý(Nature Cell Biology)Ìý
• Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate under BMP4 Induction from Human Pluripotent Stem CellsÌý(Stem Cells)Ìý
• The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture ModelsÌý(Advanced Science)Ìý
• Transcriptional and Functional Effects of Lithium in Bipolar Disorder iPSC-Derived Cortical SpheroidsÌý(Molecular Psychiatry)Ìý
• Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the BrainÌý(Journal of Neuroinflammation)Ìý

Ìý

December 2022

·ÌýÌýÌýÌýÌýÌýRNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2Ìý

·ÌýÌýÌýÌýÌýÌýEmbryonic Origins of Adult Pluripotent Stem CellsÌý

·ÌýÌýÌýÌýÌýÌýBulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoidsÌý

·ÌýÌýÌýÌýÌýÌýEffect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell lineÌýin vitroÌý

·ÌýÌýÌýÌýÌýÌýStress-Induced Reversible Cell-Cycle Arrest Requires PRC2/PRC1-Mediated Control of Mitophagy inÌýDrosophilaÌýGermline Stem Cells and Human iPSCsÌý

·ÌýÌýÌýÌýÌýÌýPlpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cellsÌý

·ÌýÌýÌýÌýÌýÌýOptimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cellsÌý

·ÌýÌýÌýÌýÌýÌýCD34^dimÌýcells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4Ìý

·ÌýÌýÌýÌýÌýÌýA Reference Human Induced Pluripotent Stem Cell Line for Large-Scale Collaborative StudiesÌý

·ÌýÌýÌýÌýÌýÌýThe Consequences of Recurrent Genetic and Epigenetic Variants in Human Pluripotent Stem CellsÌý

·ÌýÌýÌýÌýÌýÌýDialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell densityÌý

Ìý

November 2022

• Long-Range Axonal Projections of Transplanted Mouse Embryonic Stem Cell-Derived Hypothalamic Neurons into Adult Mouse BrainÌý(PLoS One)Ìý
• Modeling Placental Development and Disease Using Human Pluripotent Stem CellsÌý(Placenta)
• Transcription Factor Antagonism Regulates Heterogeneity in Embryonic Stem Cell StatesÌý(Molecular Cell)Ìý
• Membrane Potential Drives the Exit from Pluripotency and Cell Fate Commitment via Calcium and mTORÌý(Nature Communications)Ìý
• Lamin A/C-dependent Chromatin Architecture Safeguards Naïve Pluripotency to Prevent Aberrant Cardiovascular Cell Fate and FunctionÌý(Nature Communications)Ìý
• Virtual Cells in a Virtual Microenvironment Recapitulate Early Development-Like Patterns in Human Pluripotent Stem Cell ColoniesÌý(Stem Cell Reports)Ìý
• Stabilization of hESCs in Two Distinct Substrates along the Continuum of PluripotencyÌý(iScience)Ìý
• Acute Severe Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a HIF-1α and P53 Independent MechanismÌý(Scientific Reports)Ìý
• Intermediate Cells ofÌýIn VitroÌýCellular Reprogramming andÌýIn VivoÌýTissue Regeneration Require DesmoplakinÌý(Science Advances)Ìý
• Transient Inhibition of p53 Enhances Prime Editing and Cytosine Base-Editing Efficiencies in Human Pluripotent Stem CellsÌý(Nature Communications)Ìý
• Stabilization of Cell-Cell Adhesions Prevents Symmetry Breaking and Locks In Pluripotency in 3D GastruloidsÌý(Stem Cell Reports)Ìý
• Nucleosome Breathing Facilitates Cooperative Binding of Pluripotency Factors Sox2 and Oct4 to DNA(Biophysical Journal)Ìý
• Therapeutic Function of a Novel Rat Induced Pluripotent Stem Cell Line in a 6-OHDA-Induced Rat Model of Parkinson’s DiseaseÌý(International Journal of Molecular Medicine])Ìý
• Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells That Are Defective in Self-RenewalÌý(International Journal of Stem Cells)
• Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic DevelopmentÌý(Stem Cells Translational Medicine)Ìý

Ìý

October 2022

World’s first stem cell treatment for spina bifida delivered during fetal surgery!ÌýÌýÌýÌý

• Identification of Stable Housekeeping Genes for Induced Pluripotent Stem Cells and -Derived Endothelial Cells for Drug Testing (Scientific Reports)Ìý
• TGFβ Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity to Create Well-Structured Telencephalic Organoids (Stem Cell Reports)Ìý(22)00422-2
• The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells (Molecules and Cells)ÌýÌý
• Human Cellular Models for Retinal Disease: From Induced Pluripotent Stem Cells to Organoids (Retina-the Journal of Retinal and Vitreous Diseases)ÌýÌý
• Super-Enhancers Conserved within Placental Mammals Maintain Stem Cell Pluripotency (Proceedings of the National Academy of Sciences of the United States of America)ÌýÌý
• High Glucose Impairs Osteogenic Differentiation of Embryonic Stem Cells via Early Diversion of Beta-Catenin from Forkhead Box O to T Cell Factor Interaction (Birth Defects Research)Ìý

Ìý

SeptemberÌý2022

• Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid (Stem Cell Research & Therapy)Ìý
• Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells (Bioengineering & Translational Medicine)ÌýÌý
• Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage (NPJ Regenerative Medicine)Ìý
• CTCF Acetylation at Lysine 20 Is Required for the Early Cardiac Mesoderm Differentiation of Embryonic Stem Cells (Cell Regeneration)Ìý
• Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency (Nature Communications)Ìý
• Dominant Role of DNA Methylation over H3K9me3 for IAP Silencing in Endoderm (Nature Communications)Ìý
• LncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-β and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells (Nucleic Acids Research)Ìý
• Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells (Scientific Reports)ÌýÌý
• Modeling Urea Cycle Disorders Using iPSCs (NPJ Regenerative Medicine)Ìý
• BuildingÌýIn VitroÌýModels of the Brain To Understand the Role of APOE in Alzheimer’s DiseaseÌý[Life Science Alliance]ÌýÌý
• PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation (In VitroÌýToxicology in Vitro)Ìý
• Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation (Nature Communications)Ìý
• CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation (STAR Protocols)Ìý
• Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers (Aging-Us)Ìý
• Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription FactorsÌý(iScience)Ìý
• METTLing in Stem Cell and Cancer Biology (Stem Cell Reviews and Reports)Ìý
• A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production (Nature Communications)Ìý
• Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms (iScience)ÌýÌý
• Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development (Cell Stem Cell)Ìý(22)00377-0
• Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells (Biomacromolecules)Ìý
• Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem CellsÌý(Frontiers in Cell and Developmental Biology)Ìý
• Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain (Experimental Neurology)Ìý
• Modeling Metabolic Diseases and Drug Response Using Stem Cells and Organoids (Nature Reviews Endocrinology)Ìý
• Harnessing Conserved Signaling and Metabolic Pathways to Enhance the Maturation of Functional Engineered Tissues (NPJ Regenerative Medicine)Ìý
• Spatial Molecular Anatomy of Germ Layers in the Gastrulating Cynomolgus Monkey Embryo (Cell Reports)Ìý(22)01105-6
• Modeling Human Extraembryonic Mesoderm Cells Using Naive Pluripotent Stem Cells (Cell Stem Cell)Ìý(22)00337-X
• Systemic Proteomics and miRNA Profile Analysis of Exosomes Derived from Human Pluripotent Stem Cells (Stem Cell Research & Therapy)Ìý
• Robust Genome Editing via modRNA-Based Cas9 or Base Editor in Human Pluripotent Stem Cells (Cell Reports Methods)Ìý(22)00172-2
• Molecular Convergence between Down Syndrome and Fragile X Syndrome Identified Using Human Pluripotent Stem Cell Models (Cell Reports)Ìý(22)01136-6
• Modeling Human Multi-Lineage Heart Field Development with Pluripotent Stem Cells (Cell Stem Cell)Ìý(22)00343-5Ìý
• Generation of Human Induced Pluripotential Stem Cells from Individuals with Complex Heterozygous, Isogenic Corrected, and HomozygousÌýBloc1s1ÌýMutationsÌý(Stem Cell Research)Ìý

Ìý

August 2022

• DLL4 and VCAM1 Enhance the Emergence of T Cell–Competent Hematopoietic Progenitors from Human Pluripotent Stem Cells (Science Advances)Ìý
• Repeated Intravenous Administration of hiPSC-MSCs Enhance the Efficacy of Cell-Based Therapy in Tissue Regeneration (Communications Biology)Ìý

Ìý

Ìý

Ìý