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Research Interests

• To determine how chronic insufficient sleep induces inflammation and contributes to inflammatory diseases, including pain and traumatic brain injury.
• Sleep and Inflammation Laboratory.

Education

• 1979, B.S. (Biology), Walla Walla College, College Place, WA
• 1983, M.S. (Biology), Walla Walla College, College Place, WA
• 1987, Ph.D. (Zoology), Washington State University, Pullman, WA
• 1988, Postdoctoral Fellow (Physiology), University of Tennessee, Memphis, TN

Professional Experience

• 1988–1990, Instructor, Physiology & Biophysics, University of Tennessee, Memphis, TN
• 1990–1993, Assistant Professor, Physiology & Biophysics, University of Tennessee, Memphis, TN
• 1993–1997, Assistant Professor, Psychiatry, University of Texas Medical Branch, Galveston, TX
• 1997–2000, Associate Professor, Psychiatry, University of Texas Medical Branch, Galveston, TX
• 2000–2004, Associate Professor, Anesthesiology, University of Michigan, Ann Arbor, MI
• 2004–2010, Professor, Anesthesiology, University of Michigan, Ann Arbor, MI
• 2004–2010, Professor, Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI
• 2010–2017, Professor, Anesthesiology & Pain Medicine, University of Washington, Seattle, WA
• 2010-2017, Vice Chair for Basic Science; UW Medicine Research and Education Endowed Chair, Dept of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA
• 2017-Present, Professor, Department of Integrative Physiology, University of Colorado Boulder

Honors and Awards (since 2000)

• 2002-2004, Secretary Treasurer, Sleep Research Society (elected)
• 2005-2007, President-Elect, President, Past-President, Sleep Research Society (elected)
• 2005, Grass Traveling Scientist Award, University of Mississippi Medical Center
• 2005, Grass Traveling Scientist Award, Louisiana State University Health Sciences Center
• 2006, Secretary Treasure, Associated Professional Sleep Societies
• 2006, American Academy of Sleep Medicine/Pfizer Visiting Professorship in Sleep Medicine, Baylor College of Medicine
• 2007-2008, President, Associated Professional Sleep Societies
• 2006-2009, Councilor, Psychoneuroimmunology Research Society (elected)
• 2009-2010, Secretary Treasure, Psychoneuroimmunology Research Society (elected)
• 2012-present, Member, Institute of Translational Health Sciences, University of Washington, Seattle, WA
• 2013-2015, President-Elect, President, Past-President, PsychoNeuroImmunology Research Society (elected)
• 2014, Founding Chair, Gordon Research Conference on Sleep Regulation and Function

Editorial Activities (since 2000)

• 2003-2016, Associate Editor: Sleep
• 2004, Guest Editor: Brain, Behavior and Immunity; Special Issue: Sleep, Cytokines, and Immunity: Implications for Health
• 2005, Editor: SRS Basics of Sleep Guide, 1st edition
• 2006-present, Editorial Board: Brain, Behavior, and Immunity
• 2012-present, Editorial Board: Sleep Medicine Reviews
• 2015, Guest Editor: Brain, Behavior and Immunity; Special Issue: Sleep, Brain, Behavior, and Immunity
• 2015-present, Founding Editor-in-Chief: Neurobiology of Sleep and Circadian Rhythms

Recent Publications

• Davis CJ, Dunbrasky D, Oonk M, Taishi P, Opp MR, Krueger JM. The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge. Brain, Behavior and Immunity 47: 35-43, 2015.
• Febinger H, Thomasy H, Pavlova M, Ringgold K, Barf P, George A, Grillo J, Bachstetter A, Cardona A, Garcia J, Opp MR, Gemma C. CX3CR1 dictates the classical and alternative microglia phenotype shift in a mouse model of mild traumatic brain injury. Journal of Neuroinflammation 12: 154, 2015.
• Ho JM, Barf RP, Opp MR. Effects of sleep disruption and high fat intake on glucose metabolism in mice. Psychoneuroendocrinology 68: 47-56, 2016.
• Ingiosi AM, Opp MR. Sleep and immunomodulatory responses to systemic lipopolysaccharide in mice selectively expressing interleukin-1 receptor 1 on neurons or astrocytes. GLIA 64: 780-791. 2016.
• Ingiosi AM, Raymond RM, Pavlova MN, Opp MR. Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep. Brain, Behavior, and Immunity 48: 244-257, 2015.
• Kozachik SL, Opp MR, Page GG. Recovery sleep does not mitigate the effects of prior sleep loss on paclitaxel-induced mechanical hypersensitivity in Sprague-Dawley rats. Biological Research for Nursing 17: 207-213, 2015.
• Opp MR, George A, Ringgold KM, Hansen KM, Bullock KM, Banks WA. Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and transport of tumor necrosis factor-α in aging. Brain, Behavior, and Immunity 50: 259-265, 2015.
• Page GG, Opp MR, Kozachik SL. Sex differences in sleep, anhedonia, and HPA axis activity in a rat model of chronic social defeat. Neurobiology of Stress 3: 105-113, 2016.
• Sutton BC, Opp MR. Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization. Brain, Behavior and Immunity 44: 213-220, 2015.
• Thomasy HE, Febinger HY, Ringgold KM, Gemma C, Opp MR. Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury. Neurobiology of Sleep and Circadian Rhythms 2: 71-84, 2017.
• Thomasy HE, Febinger HY, Ringgold KM, Gemma C, Opp MR. Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury. Neurobiology of Sleep and Circadian Rhythms 2: 71-84, 2017.