GEM: Genetics, Exercise, and Methylation
GEM: Genetics, Exercise, and Methylation
DNA Methylation and Cancer Prevention: Duration and Intensity of Exercise
PI: Dr. Angela Bryan
We have shown that increased physical activity is associated with decreased DNA methylation—a potential biomarker for cancer risk—among healthy adults. The next step is to better understand the dose response relationship of exercise on these epigenetic modifications that may ultimately put a woman at risk for breast cancer. The purpose of this study was to explore the influence of exercise volume on DNA methylation controlling for both intensity and duration of exercise. We focused this study on sedentary women, a group at higher risk for the development of breast cancer than regularly exercising women.