Uncertainty is abound in the international trade landscape. As the U.S. and Colorado economies continue their recoveries, the breakdown of the global supply chain, rising prices, and the continued presence of COVID-19 remain headwinds against a return to normalcy. This publication of the Colorado Business Review discusses these concerns with articles written by business and education leaders. The issue describes the unequal distribution of COVID-19 vaccines around the globe, the expansion of export potential in the Colorado economy, the importance of free-trade agreements to growth and certainty in the economy, as well as the size and scope of Colorado international trade.