Heart and Muscle Biology

Heart and Muscle Biology

Labs studying Heart and Muscle Biology

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Anseth Lab

The Anseth Lab designs innovative biomaterials with programmed, tunable properties and are pioneers in stem cell and organoid technologies. Their engineered cell-material constructs have applications from understanding development and disease to tissue replacement and regeneration.Ìý

Burdick Biomaterials and Biofabrication Lab

The Burdick Biomaterials and Biofabrication Lab designs new biomaterials and biofabrication technologies for lab-created microtissues that model health and disease and for clinical use. They are leaders in developing self-healing, injectable gels whose uses range from drug delivery to tissue patching, such as heart attack damage.Ìý

Calve Lab

The Calve Musculoskeletal ExtracellularÌý MatrixÌý Lab characterizes the material properties of assembling tissues to establish design parameters for regenerative therapies. They are particularly interested in the composition and spatial organization of the extracellular matrix, its influence on muscle mechanical properties, and the application of hyaluronic acid to muscle repair and regeneration.

Leinwand Lab

The Leinwand Lab are leaders in the molecular cardiology field. Their interdisciplinary studies close the gap between disease-causing mutations and the manifestations of heart disease. Moreover, they are pioneers in examining disease modifying factors such as biological sex, diet, exercise, and hormone status, and they specialize in detailed analyses of the motor protein myosin. Their discoveries underpinned the first ever approved drug for the genetic heart disease hypertrophic cardiomyopathy.ÌýÌý

Neu Lab

The Neu Soft Tissue Bioengineering Lab develops technology for fundamental study and engineering of connective and cardiac tissues to inform new therapies for disorders of the connective and cardiac tissues, including arthritis and fibrosis. Biomechanics is a central lab theme, and they span multiple engineering and biology disciplines, including mechanical, electrical, micro/nanotechological, biochemical, and physiological subspecialties.Ìý

Olwin Lab

The Olwin Lab examines the mechanisms regulating the growth, differentiation and self-renewal of skeletal muscle stem cells (satellite cells) for eventual use in cell-based gene therapy approaches. They use molecular genetics, cell biology, and cellular biochemistry to understand satellite cell self-renewal and to investigage age-related decline and neuromuscular diseases.Ìý

Welker Lab

The Welker Lab works on movement assistive devices at the intersection of biomechanics, haptics, and robotics. Their work on the human-device as a system aims to improve movement for individuals with impairments or injuries and to reduce injury or prevent fatigue in the healthy population.